VECTRON™ T500, a new insecticide and chemical class developed by Mitsui Chemicals Group and IVCC (Innovative Vector Control Consortium), has achieved WHO prequalification. Developed specifically for indoor residual spraying (IRS) to support insecticide resistance management (IRM) strategies, VECTRON™ T500 is a new tool to employ against pyrethroid resistant mosquitoes, providing countries with new options to combat malaria. VECTRON™ T500’s active ingredient, TENEBENAL™, acts as an antagonist on the GABA receptor of insects, blocking inhibitory neurotransmission, causing death in exposed insects. As TENEBENAL™ binds to a newly discovered site on the GABA receptor, the Insecticide Resistance Action Committee (IRAC) has assigned it to a new classification group.

With long residual activity when sprayed on a range of wall types, and no known cross resistance, this is a promising new tool for vector control.

References

Govoetchan, R., Fongnikin, A., Syme, T. et al. VECTRON™ T500, a new broflanilide insecticide for indoor residual spraying, provides prolonged control of pyrethroid-resistant malaria vectors. Malar J 21, 324 (2022). https://doi.org/10.1186/s12936-022-04336-x

VectronT500. https://www.vectront500.com/. Accessed 13 March 2023.